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C.S. Peirce, the founder of pragmatism, was an American philosopher and mathematician whose influence has been enormous on the field of semiotics. Merrell uses Pierce's theories to reply to the all-important question: "What and where is meaning?"

Focusing on analogical sensing, rather than digital reasoning, Merrell argues that human sensation and cognition should be thought of in terms of continually changing signs that can be accounted for in terms of topological forms.

Following Sebeok, Merrell reminds us that `any and all investigation of nature and of the nature of signs and life must ultimately be semiotic in nature.'